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Insulin Resistance, Pre-Diabetes and Metabolic Syndrome

Insulin resistance is a silent condition that increases the chances of developing diabetes and heart disease. Learning about insulin resistance is the first step you can take toward making lifestyle changes that will help you prevent diabetes and other health problems.


What does insulin do?

After you eat, the food is broken down into glucose, the simple sugar that is the main source of energy for the body's cells. But your cells cannot use glucose without insulin, a hormone produced by the pancreas. Insulin helps the cells take in glucose and convert it to energy. When the pancreas does not make enough insulin or the body is unable to use the insulin that is present, the cells cannot use glucose. Excess glucose builds up in the bloodstream, setting the stage for diabetes.
Being obese or overweight affects the way insulin works in your body. Extra fat tissue can make your body resistant to the action of insulin, but exercise helps insulin work well.







How is insulin resistance, pre-diabetes, and type 2 diabetes linked? you have insulin resistance, your muscle, fat, and liver cells do not use insulin properly. The pancreas tries to keep up with the demand for insulin by producing more. Eventually, the pancreas cannot keep up with the body's need for insulin, and excess glucose builds up in the bloodstream. Many people with insulin resistance have high levels of blood glucose and high levels of insulin circulating in their blood at the same time.
People with blood glucose levels that are higher than normal but not yet in the diabetic range have “pre-diabetes.” Doctors sometimes call this condition impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), depending on the test used to diagnose it. Pre-diabetes is becoming more common in the United States, according to new estimates provided by the U.S. Department of Health and Human Services. About 40 percent of U.S. adults ages 40 to 74—or 41 million people—had pre-diabetes in 2000. New data suggest that at least 54 million U.S. adults had pre-diabetes in 2002.
If you have pre-diabetes, you have a higher risk of developing type 2 diabetes, formerly called adult-onset diabetes or noninsulin-dependent diabetes. Studies have shown that most people with pre-diabetes go on to develop type 2 diabetes within 10 years, unless they lose 5 to 7 percent of their body weight—which is about 10 to 15 pounds for someone who weighs 200 pounds—by making modest changes in their diet and level of physical activity. People with pre-diabetes also have a higher risk of heart disease.
Type 2 diabetes is sometimes defined as the form of diabetes that develops when the body does not respond properly to insulin, as opposed to type 1 diabetes, in which the pancreas makes no insulin at all. At first, the pancreas keeps up with the added demand by producing more insulin. In time, however, it loses the ability to secrete enough insulin in response to meals.
Insulin resistance can also occur in people who have type 1 diabetes, especially if they are overweight.



What causes insulin resistance?

Because insulin resistance tends to run in families, we know that genes are partly responsible. Excess weight also contributes to insulin resistance because too much fat interferes with muscles' ability to use insulin. Lack of exercise further reduces muscles' ability to use insulin.
Many people with insulin resistance and high blood glucose have excess weight around the waist, high LDL (bad) blood cholesterol levels, low HDL (good) cholesterol levels, high levels of triglycerides (another fat in the blood), and high blood pressure, all conditions that also put the heart at risk. This combination of problems is referred to as the metabolic syndrome, or the insulin resistance syndrome (formerly called Syndrome X).

What are the symptoms of insulin resistance and pre-diabetes?

Insulin resistance and pre-diabetes usually have no symptoms. You may have one or both conditions for several years without noticing anything. If you have a severe form of insulin resistance, you may get dark patches of skin, usually on the back of your neck. Sometimes people get a dark ring around their neck. Other possible sites for these dark patches include elbows, knees, knuckles, and armpits. This condition is called acanthosis nigricans.
If you have a mild or moderate form of insulin resistance, blood tests may show normal or high blood glucose and high levels of insulin at the same time.

Do you have insulin resistance or pre-diabetes?

Anyone 45 years or older should consider getting tested for diabetes. If you are overweight and aged 45 or older, it is strongly recommended that you get tested. You should consider getting tested if you are younger than 45, overweight, and have one or more of the following risk factors:

  • family history of diabetes
  • low HDL cholesterol and high triglycerides
  • high blood pressure
  • history of gestational diabetes (diabetes during pregnancy) or gave birth to a baby weighing more than 9 pounds
  • minority group background (African American, American Indian, Hispanic American/Latino, or Asian American/Pacific Islander) and pre-diabetes can be detected with one of the following tests: fasting glucose test measures your blood glucose after you have gone overnight without eating. This test is most reliable when done in the morning. Fasting glucose levels of 100 to 125 mg/dL are above normal but not high enough to be called diabetes. This condition is called pre-diabetes or impaired fasting glucose, and it suggests that you have probably had insulin resistance for some time. IFG is considered a pre-diabetic state, meaning that you are more likely to develop diabetes but do not have it yet.
A glucose tolerance test measures your blood glucose after an overnight fast and 2 hours after you drink a sweet liquid provided by the doctor or laboratory. If your blood glucose falls between 140 and 199 mg/dL 2 hours after drinking the liquid, your glucose tolerance is above normal but not high enough for diabetes. This condition, also a form of pre-diabetes, is called impaired glucose tolerance and, like IFG, it points toward a high story of insulin resistance and a risk for developing diabetes.
These tests give only indirect evidence of insulin resistance. The test that most accurately measures insulin resistance is too complicated and expensive to use as a screening tool in most doctors' offices. The test, called the euglycemic clamp, is a research tool that helps scientists learn more about sugar metabolism problems. Insulin resistance can also be assessed with measurement of fasting insulin. If conventional tests show that you have IFG or IGT, your doctor may suggest changes in diet and exercise to reduce your risk of developing diabetes.
If your blood glucose is higher than normal but lower than the diabetes range, have your blood glucose checked in 1 to 2 years.

Lab Tests and What They Show

    • Blood glucose. High blood glucose may be a sign that your body does not have enough insulin or does not use it well. However, a fasting measurement or oral glucose tolerance test gives more precise information.
    • Insulin. An insulin measurement helps determine whether a high blood glucose reading is the result of insufficient insulin or poor use of insulin.
    • Fasting glucose. Your blood glucose level should be lower after several hours without eating. After an overnight fast, the normal level is below 100 mg/dL. If it is in the 100 to 125 mg/dL range, you have impaired fasting glucose or pre-diabetes. A result of 126 or higher, if confirmed on a repeat test, indicates diabetes.
    • Glucose tolerance. Your blood glucose level will be higher after drinking a sugar solution, but it should still be below 140 mg/dL 2 hours after the drink. If it is higher than normal (in the 140 to 199 mg/dL range) 2 hours after drinking the solution, you have IGT or pre-diabetes, which is another strong indication that your body has trouble using glucose. A level of 200 or higher, if confirmed, means diabetes is already present.






    Can you reverse insulin resistance?

    Yes. Physical activity and weight loss make the body respond better to insulin. By losing weight and being more physically active, you may avoid developing type 2 diabetes. In fact, a major study has verified the benefits of healthy lifestyle changes and weight loss. In 2001, the National Institutes of Health completed the Diabetes Prevention Program (DPP), a clinical trial designed to find the most effective ways of preventing type 2 diabetes in overweight people with pre-diabetes. The researchers found that lifestyle changes reduced the risk of diabetes by 58 percent. Also, many people with pre-diabetes returned to normal blood glucose levels.
    The main goal in treating insulin resistance and pre-diabetes is to help your body relearn to use insulin normally. You can do several things to help reach this goal.

    Be Active and Eat Well$File/BAEW.jpgPhysical activity helps your muscle cells use blood glucose because they need it for energy. Exercise makes those cells more sensitive to insulin.
    The DPP confirmed that people who follow a low-fat, low-calorie diet and who increase activities such as walking briskly or riding a bike for 30 minutes, five times a week, have a far smaller risk of developing diabetes than people who do not exercise regularly. The DPP also reinforced the importance of a low-calorie, low-fat diet. Following a low-calorie, low-fat diet can provide two benefits. If you are overweight, one benefit is that limiting your calorie and fat intake can help you lose weight. DPP participants who lost weight were far less likely to develop diabetes than others in the study who remained at an unhealthy weight. Increasing your activity and following a low-calorie, low-fat diet can also improve your blood pressure and cholesterol levels and has many other health benefits.





  have established some numbers to help people set goals that will reduce their risk of developing glucose metabolism problems.

    • Weight. Body mass index (BMI) is a measure used to evaluate body weight relative to height. You can use BMI to find out whether you are underweight, normal weight, overweight, or obese. Use the Body Mass Index Table to find your BMI.
      • Find your height in the left-hand column.
      • Move across in the same row to the number closest to your weight.
      • The number at the top of that column is your BMI. Check the word above your BMI to see whether you are normal weight, overweight, or obese. If you are overweight or obese, talk with your doctor about ways to lose weight to reduce your risk of diabetes.



    • Blood pressure. Blood pressure is expressed as two numbers that represent pressure in your blood vessels when your heart is beating (systolic pressure) and when it is resting (diastolic pressure). The numbers are usually written with a slash—for example, 140/90, which is expressed as "140 over 90." For the general population, blood pressure below 130/85 is considered normal, although people whose blood pressure is slightly elevated and who have no additional risk factors for heart disease may be advised to make lifestyle changes—that is, diet and exercise—rather than take blood pressure medicines. People who have diabetes, however, should take whatever steps necessary, including lifestyle changes and medicine, to reach a blood pressure goal of below 130/80.
    • Cholesterol. Your cholesterol is usually reported with three values: low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and total cholesterol. LDL cholesterol is sometimes called "bad" cholesterol, while HDL cholesterol is called "good" cholesterol. To lower your risk of cardiovascular problems if you have diabetes, you should try to keep your LDL cholesterol below 100 and your total cholesterol below 200.

    If you have metabolic syndrome, your doctor may recommend weight loss with diet and exercise, as well as medication to lower your cholesterol and blood pressure levels. Smoking

    In addition to increasing your risk of cancer and cardiovascular disease, smoking contributes to insulin resistance. Quitting smoking is not easy, but it could be the single smartest thing you can do to improve your health. You will reduce your risk for respiratory problems, lung cancer, and diabetes.





    Can medicines help? classes of drugs can improve response to insulin and are used by prescription for type 2 diabetes—biguanides and thiazolidinediones. Other medicines used for diabetes act by other mechanisms. Alpha-glucosidase inhibitors restrict or delay the absorption of carbohydrates after eating, resulting in a slower rise of blood glucose levels. Sulfonylureas and meglitinides increase insulin production.
    The DPP showed that the diabetes drug metformin, a biguanide, reduced the risk of diabetes in those with pre-diabetes but was much less successful than losing weight and increasing activity. In another study, treatment with troglitazone, a thiazolidinedione later withdrawn from the market following reports of liver toxicity, delayed or prevented type 2 diabetes in Hispanic women with a history of gestational diabetes. Acarbose, an alpha-glucosidase inhibitor, has been effective in delaying development of type 2 diabetes. Additional studies using other diabetes medicines and some types of blood pressure medicines to prevent diabetes are under way. No drug has been approved by the Food and Drug Administration (FDA) specifically for insulin resistance or pre-diabetes.



    Metabolic Syndrome

    Metabolic syndrome is the name for a group of risk factors linked to overweight and obesity that increase your chance for heart disease and other health problems such as diabetes and stroke. The term “metabolic” refers to the biochemical processes involved in the body’s normal functioning. Risk factors are behaviors or conditions that increase your chance of getting a disease. In this article, “heart disease” refers to coronary heart disease. Other terms used for metabolic syndrome are insulin resistance syndrome and syndrome X.

    How does it occur?

    Overweight, poor diet, a lack of exercise, and other unhealthy lifestyle habits, such as smoking, appear to be factors that contribute to metabolic syndrome. It tends to run in families, so the genes you inherit also play a role.

    What are the symptoms?

    Metabolic syndrome is made up of a group of factors that can increase risk even if they are only moderately raised (borderline-high risk factors). Metabolic syndrome itself usually has no symptoms. Most of the risk factors linked to metabolic syndrome have no signs or symptoms, although a large waistline is a visible sign.
    Some people may have symptoms of high blood sugar (if diabetes is present) or, occasionally, high blood pressure. Symptoms of high blood sugar often include increased thirst; increased urination, especially at night; fatigue (tiredness); and blurred vision. High blood pressure is generally considered to have no signs or symptoms. However, a few people in the early stages of high blood pressure may have dull headaches, dizzy spells, or more nosebleeds than usual.

    How is it diagnosed?
    The diagnosis of metabolic syndrome is based on the results of a physical exam and blood tests. To be diagnosed with metabolic syndrome, you must have at least three out of five of the following risk factors:

    • A large waistline. This means that you carry excess weight around your waist (abdominal obesity). Your doctor will measure your waist to determine whether you have abdominal obesity. A waist measurement of 35 inches or more for women and 40 inches or more for men is a component of metabolic syndrome and indicates an increased risk for heart disease and other health problems. A large waistline also is called “having an apple shape.”
    • A higher than normal triglyceride level, or you’re on medicine to treat high triglycerides. Triglycerides are a type of fat found in the blood. A triglyceride level of 150 mg/dL or higher is a component of metabolic syndrome.
    • A lower than normal level of HDL cholesterol (high-density lipoprotein cholesterol), or you’re on medicine to treat low HDL. HDL is considered “good” cholesterol because it lowers your chances of heart disease. An HDL cholesterol level less than 50 mg/dL for women and less than 40 mg/dL for men is a component of metabolic syndrome.
    • Higher than normal blood pressure, or you’re on medicine to treat high blood pressure. A blood pressure of 130/85 or higher is a component of metabolic syndrome. If only one of your two blood pressure numbers is high, it’s still a risk factor for metabolic syndrome.
    • Higher than normal fasting blood sugar (glucose), or you’re on medicine to treat high blood sugar. A normal fasting blood sugar is less than 100 mg/dL. Fasting blood sugar between 100 and 125 mg/dL is considered prediabetes. Fasting blood sugar of 126 mg/dL or higher is considered diabetes. A fasting blood sugar of 100 mg/dL or higher (prediabetes or diabetes) is a component of metabolic syndrome.

    About 85 percent of people who have type 2 diabetes (the most common type) also have metabolic syndrome. These people have a much higher risk for heart disease than the 15 percent of people who have type 2 diabetes, but don’t have metabolic syndrome.

    How is it treated?

    The most important part of treatment is lifestyle change: exercise to improve fitness and lose weight. Eating a healthier diet is part of this change. Your healthcare provider may prescribe medicines to treat other risk factors. These medicines may include aspirin, blood pressure medicines, and cholesterol drugs. Aspirin may help prevent blood clots, strokes, and heart attacks. Blood pressure medicines can reduce your blood pressure to help prevent stroke and heart damage. And cholesterol drugs can bring down high triglyceride levels and raise your HDL, or "good" cholesterol, levels.

    How long will the effects last?

    If metabolic syndrome is not treated, you are much more likely to have a heart attack, stroke, or diabetes. Increasing your physical activity and losing weight can help prevent development of diabetes. Blood glucose levels may return to normal. These improvements in lifestyle, including a healthier diet plus medicines if needed, can also improve blood pressure and cholesterol levels, thus reducing your risk for heart disease. Making lifestyle changes and taking medicines as prescribed can add years to your life.

    How can I take care of myself?

    • Get regular aerobic exercise (like walking at a good pace) according to your healthcare provider's recommendations. Being more active can help improve every one of the risk factors for metabolic syndrome.
    • Replace some of the animal fats, sugars, and white flour products in your diet with more olive and canola oil, nuts, avocados and fish (especially salmon, mackerel and tuna), fruits, vegetables and whole-grain breads and cereals.
    • Lose weight.
    • Take all medicines according to your provider's instructions.
    • If you are a smoker, quit.
    • Keep your follow-up appointments with your healthcare provide.

    Points to Remember

    • Glucose is the simple sugar that is the main source of energy for the body's cells.
    • Insulin helps cells take in blood glucose and convert it to energy.
    • If you have insulin resistance, your body's cells do not respond well to insulin.
    • Insulin resistance is a stepping-stone to type 2 diabetes.
    • Lack of exercise and excess weight contribute to insulin resistance.
    • Engaging in moderate physical activity and maintaining proper weight can help prevent insulin resistance.
    • Insulin resistance plays a role in the development of cardiovascular disease, which damages the heart and blood vessels.
    • Controlling blood pressure and LDL cholesterol and not smoking can also help prevent cardiovascular problems.
    • The Diabetes Prevention Program confirmed that exercise and a low-calorie, low-fat diet are the best ways to prevent type 2 diabetes



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    125,000 people will have amputations this year from complications of diabetes. However, Dr. Gupta has not had a single amputation in 22 years of practice.

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